发明名称 |
Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof |
摘要 |
A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient. |
申请公布号 |
US9241934(B2) |
申请公布日期 |
2016.01.26 |
申请号 |
US201414542396 |
申请日期 |
2014.11.14 |
申请人 |
Vertex Pharmaceuticals Incorporated |
发明人 |
Verwijs Marinus Jacobus;Alargova Rossitza Gueorguieva;Kaushik Ritu Rohit;Kadiyala Irina Nikolaevna;Young Christopher |
分类号 |
A61K31/443;C07D405/12;A61K9/20 |
主分类号 |
A61K31/443 |
代理机构 |
Finnegan, Henderson, Farabow, Garrett & Dunner, LLP |
代理人 |
Finnegan, Henderson, Farabow, Garrett & Dunner, LLP |
主权项 |
1. A tablet for oral administration comprising:
a. (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid) Form I, ranging from about 40 wt % to about 60 wt % by weight of the tablet; b. a filler; c. a disintegrant; d. a surfactant; e. a lubricant; and f. at least one of a binder and a glidant. |
地址 |
Boston MA US |