Immunoglobulin preparation

摘要

The present invention relates to the use of proline for reducing the viscosity of a protein preparation.

主权项

1. A process for preparing an immunoglobulin preparation, wherein the process comprises adding proline to an initial immunoglobulin preparation comprising less than 15% (m/v) immunoglobulin, and concentrating the initial immunoglobulin preparation to prepare a final immunoglobulin preparation comprising at least 18% (m/v) immunoglobulin, and wherein proline is added such that the viscosity of the final immunoglobulin preparation is less than 13 mPa· s as measured by a falling ball viscosimeter at 20.0° C.