发明名称 |
(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-piperaziner som kinaseinhibitorer til behandling af cancer og inflammation |
摘要 |
<p>Inhibitors of LIM kinase 2 of the following formula are disclosed, along with pharmaceutical compositions comprising them and methods of their use, in particular for treatment of inflammatory and cancerous and ocular diseases.
X is O or NR A ;
A is cycloalkyl, aryl or heterocyclyl;
R A is hydrogen, cyano, nitro, RA 1 , SO 2 RA 1 or SO 2 N(RA 1 ) 2 ;
each R B is independently hydrogen or alkyl.
The other variables are as defined in the claims.</p> |
申请公布号 |
DK2188289(T3) |
申请公布日期 |
2016.01.25 |
申请号 |
DK20080782684T |
申请日期 |
2008.08.08 |
申请人 |
LEXICON PHARMACEUTICALS, INC. |
发明人 |
HARRISON, BRYCE ALDEN;KIMBALL, SPENCER DAVID;MABON, ROSS;RAWLINS, DAVID BRENT;RICE, DENNIS S.;VORONKOV, MICHAEL VICTOR;ZHANG, YULIAN |
分类号 |
C07D487/04;C07D519/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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