USE OF COLLAGEN TYPE VII FOR MAINTAINING AND RE-INDUCING OSTEOGENIC ABILITIES OF MESENCHYMAL STEM CELLS

摘要

Abstract This invention provides methods of inducing and maintaining osteogenic potential in mesenchymal stem cells and compositions for doing the same. The compositions this invention comprise collagen 7 (C7), the NCI domain of C7, or the 27kD fragment of C7. Also provided are methods for treating bone diseases and correcting bone defects by applying compositions of this invention or by first priming ex vivo mesenchymal stem cells with compositions of this invention and then applying the primed mesenchymal stem cells to the patient. The invention further provides a mesenchymal stem cell osteogenesis induction kit. 2505423vl