HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL

摘要

The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns heterocyclic compounds (e.g., compounds according to any of Formulas (I)-(X) or Compounds (1)-(92) of Table 1) that are that are useful in treatment of conditions such as epilepsy, cancer, pain, migraine, Parkinson's Disease, mood disorders, schizophrenia, psychosis, tinnitus, amyotrophic lateral sclerosis, glaucoma, ischemia, spasticity disorders, obsessive compulsive disorder, restless leg syndrome and Tourette syndrome.

主权项

1. A compound of Formula I: wherein R1 is H or optionally substituted C1-C6 alkyl; or R1 combines with R2 to form an optionally substituted 5- to 6-membered heterocyclyl; or R1 combines with Ar to form an optionally substituted bicyclic 9- to 10-membered heterocyclyl; R2 is H or optionally substituted C1-C6 alkyl, or R2 combines with R1 to form an optionally substituted 5- to 6-membered heterocyclyl; m is 0 or 1; n is 0 or 1; R3 is H, optionally substituted C1-C6 alkyl, or optionally substituted phenyl; or R3 combines with R1 to form an optionally substituted 5- to 6-membered heterocyclyl; or R3 combines with Ar to form an optionally substituted bicyclic 9- to 10-membered cycloalkyl or aryl group; and Ar is optionally substituted phenyl; or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof.