| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to a method of producing carrier-free high-purityLu compounds for medical purposes and/or diagnostic purposes. A method of producingLu compounds fromYb compounds, irradiated with thermal neutrons, includes loading into a first column, filled with a cation-exchange material, starting materials dissolved in mineral acid and containingLu andYb in an approximate weigh ratio of 1:10to 1:10; replacing protons of the cation-exchange material with ammonium ions using NHCl solution, washing the cation-exchange material with water; connecting the outlet opening of the first column and the inlet opening of a second column; feeding water and a chelating agent into the inlet opening of the first column in order to eluteLu compounds from the first and second columns; determining the level of radioactive radiation at the outlet of the second column to confirm elution of theLu compounds; collecting the firstLu eluate from the outlet opening of the second column into a vessel; protonating the chelating agent; loading the final column by continuously feeding the obtainedLu eluate into the inlet opening of the final column; washing off the chelating agent with diluted mineral acid; removing traces of ions of other metals from theLu solution by washing the cation-exchange material of the final column with mineral acid in different concentrations and elutingLu ions from the final column with highly concentrated mineral acid.EFFECT: invention enables to obtain milligram amounts of carrier-free high-purityLu compounds.16 cl, 4 dwg, 1 ex |
