发明名称 |
HIGH DRUG LOAD BUPRENORPHINE MICROSPHERES AND METHOD OF PRODUCING THE SAME |
摘要 |
A sustained release microsphere formulation with a high drug load may be formed by a continuous oil-in-water emulsion process by combining an organic dispersed phase with an aqueous continuous phase. The dispersed phase may include an encapsulating polymer, a primary solvent, such as dichloromethane, a pharmaceutically effective amount of an active agent having a solubility relative to the dispersed phase, and a co-solvent, such as benzyl alcohol, which is capable of increasing the solubility of the active agent relative to the dispersed phase. The continuous phase may include an aqueous solution of polyvinyl alcohol and water. |
申请公布号 |
EP2968577(A1) |
申请公布日期 |
2016.01.20 |
申请号 |
EP20140764439 |
申请日期 |
2014.03.14 |
申请人 |
OAKWOOD LABORATORIES, LLC;RICHEY, TRACY;THANOO, BAGAVATHIKANUN, CHITHAMBARA |
发明人 |
RICHEY, TRACY;THANOO, BAGAVATHIKANUN, CHITHAMBARA |
分类号 |
A61K31/485;A61K9/10;A61K9/50 |
主分类号 |
A61K31/485 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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