发明名称 |
COMPOSITIONS WITH THIXOTROPY AND ENHANCED DISSOLUTION REPRODUCIBILITY AND STABILITY |
摘要 |
The present disclosure provides extended release compositions including, formulations that comprise such compositions, which exhibit desirable dissolution of an active agent while maintaining its physical stability in a dosage form including, for example, providing reduced sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided. |
申请公布号 |
EP2970253(A1) |
申请公布日期 |
2016.01.20 |
申请号 |
EP20140765802 |
申请日期 |
2014.03.14 |
申请人 |
DURECT CORPORATION |
发明人 |
ZAMLOOT, MICHAEL S.;FU, ROGER;YUM, SU IL;CHAO, WENDY;SU, HUEY-CHING |
分类号 |
C07D471/00;A61K9/48;A61K31/485 |
主分类号 |
C07D471/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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