PREDICTING THE RISKS OF MULTIPLE HEALTHCARE-RELATED OUTCOMES VIA JOINT COMORBIDITY DISCOVERY

摘要

A mapping matrix, which maps from original features of an electronic health record database to higher level latent factors, is initialized. For each of one or more target diseases, regression coefficients are updated over the higher level latent factors, based on said initialized mapping matrix, a data matrix containing said original features, and a label vector of corresponding responses. Said mapping matrix is updated based on said updated regression coefficients. Said steps of updating said regression coefficients and updating said mapping matrix are repeated until convergence is achieved, to obtain a final mapping matrix and a final set of regression coefficients.

主权项

1. A method comprising the steps of:
initializing a mapping matrix which maps from original features of an electronic health record database to higher level latent factors; for each of one or more target diseases, updating regression coefficients over the higher level latent factors, based on said initialized mapping matrix, a data matrix containing said original features, and a label vector of corresponding responses; updating said mapping matrix based on said updated regression coefficients; and repeating said steps of updating said regression coefficients and updating said mapping matrix until convergence is achieved, to obtain a final mapping matrix and a final set of regression coefficients.