SYSTEM AND METHOD FOR BLOOD SEPARATION BY MICROFLUIDIC ACOUSTIC FOCUSING

摘要

Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.

主权项

1. A blood cleansing device comprising:
a thermoplastic microfluidic separation channel having an upstream portion and downstream portion, the separation channel comprising: a first inlet configured to introduce flowing whole blood into a proximal portion of the separation channel, the whole blood including plasma, a plurality of formed elements and a plurality of undesirable particles; a first outlet at the downstream portion of the separation channel positioned substantially along the longitudinal axis of the separation channel; a second outlet at the downstream portion positioned adjacent a first wall of the separation channel; and an acoustic transducer positioned adjacent to the separation channel for imposing a standing acoustic wave transverse to the flow of blood through a particle migration region of the separation channel, wherein a width of the separation channel is between about 30% and 45% of a wavelength of the standing acoustic wave.