COMPOSITIONS AND METHODS FOR TREATING CANCER

摘要

The instant invention relates to methods for the treatment of WEE1 kinase associated cancer by administering a WEE1 inhibitor, wherein the WEE1 inhibitor is WEE1-1 or a pharmaceutically acceptable salt thereof, or WEE1-2 or a pharmaceutically acceptable salt thereof. In another embodiment, the invention relates to a method for treating a WEE1 kinase associated cancer patient, comprising administering a WEE1 inhibitor, wherein the cancer cells of said patient to be treated are characterized by low expression levels of PKMYT1.

主权项

1. A method for treating a patient diagnosed with a WEE1 kinase associated cancer with a WEE1 inhibitor comprising:
(a) measuring the gene expression level of PKMYT1 in a biological sample comprising cancer cells obtained from said patient and in a control sample; (b) determining whether the gene expression level in said patient sample is above or below the level of that in said control sample; (c) selecting said patient for treatment with a WEE1 inhibitor, wherein the level of the predictive biomarker from said patient sample is below that of the control sample; and (d) administering a WEE1 inhibitor to the selected patient.