PREGNANE-OXIMINO-AMINOALKYLETHERS AND PROCESS FOR PREPARATION THEREOF, USEFUL AS ANTIDIABETIC AND ANTIDYSLIPIDEMIC AGENTS

摘要

The present invention relates to the synthesis of pregnane-oximino-aminoalkyl-ethers and their antidiabetic and antidyslipidemic activities. More particularly, the invention relates to the synthesis of compounds of formula 3 and biological profile thereof. Further the invention relates to compounds of formula 3 and pharmaceutically acceptable salts thereof.

主权项

1. A compound of formula 3 or a pharmaceutically acceptable salt thereof: wherein R is selected from the group consisting of hydrogen (H), n-butyl, benzyl or where n is 2 or 3, R1 and R2 are independently selected from the group consisting of H and an alkyl group, or R1 and R2 together form a cyclic system wherein the cyclic system is selected from the group consisting of 4-phenyl-piperazine-1-yl, 4-(2-methoxy phenyl)-piperazinyl, pyrrolidinyl, piperidinyl, azepanyl and morpholine; R3 is H or OH, wherein the alkyl group is selected from the group consisting of ethyl, isopropylamine, diisopropyl and t-butyl amine.