Treatment of insulin gene (INS) related diseases by inhibition of natural antisense transcript to an insulin gene (INS)

摘要

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an Insulin gene (INS), in particular, by targeting natural antisense polynucleotides of an Insulin gene (INS). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Insulin Gene (INS).

主权项

1. A method of upregulating a function of and/or the expression of an Insulin gene (INS) polynucleotide having SEQ ID NO: 1 in patient cells or tissues in vivo or in vitro comprising: contacting said patient cells or tissues with at least one oligonucleotide of 10 to 30 nucleotides in length that specifically targets and hybridizes to a region of a natural antisense polynucleotide of the Insulin gene (INS) polynucleotide wherein said natural antisense polynucleotide is selected from the group consisting of SEQ ID NOS: 2 and 3; thereby upregulating a function of and/or the expression of the Insulin gene (INS) polynucleotide in patient cells or tissues in vivo or in vitro.