| 摘要 |
The present invention provides an industrially advantageous method of producing a pyridazinone compound. The present invention relates to the following method of producing a pyridazinone compound: Formula (II), (IIIa), (IV) or (IV″), Formula (IIIb), (Vb) or (V″b), Formula (VI), (I) or (I″), wherein each symbol is as described in the specification.; |
| 主权项 |
1. A method of producing a compound represented by the formula (I) or formula (I′): wherein R1 and R2 are each independently a hydrogen atom or a substituent (excluding a benzyloxy group), Ring A is an optionally substituted aromatic ring, and R7 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, provided that a compound wherein R1 and R2 are same groups is excluded, or a mixture thereof or a salt thereof, which comprises step (1): a step of reacting a compound represented by the formula (II): wherein each symbol is as defined above, or a salt thereof, with a compound represented by the formula (IIIa): wherein R3a, R4a, R5a and R6a are each independently an optionally substituted hydrocarbon group, or a salt thereof, to give a compound represented by the formula (IV) or formula (IV′): wherein each symbol is as defined above, or a mixture thereof or a salt thereof; step (2): a step of reacting the compound represented by the formula (IV) or formula (IV′) or a mixture thereof or a salt thereof with a compound represented by the formula (IIIb): wherein R3b, R4b, R5b and R6b are each independently an optionally substituted hydrocarbon group, or a salt thereof, to give a compound represented by the formula (Vb) or formula (V′b): wherein each symbol is as defined above, or a mixture thereof or a salt thereof; and step (3): a step of reacting the compound represented by formula (Vb) or formula (V′b) or a mixture thereof or a salt thereof, with a compound represented by the formula (VI):
R7NH—NH2 (VI) wherein each symbol is as defined above, or a salt thereof. |
