ビタミンＫエポキシド還元酵素遺伝子内の一塩基多型とワルファリン用量とを相関させるための方法および組成物

摘要

The present invention provides a host cell comprising a heterologous nucleic acid encoding a vitamin K epoxide reductase (VKOR) and a nucleic acid encoding a vitamin K dependent protein, wherein the nucleic acids encoding both the VKOR and Vitamin K dependent protein are expressed in said host cell. The invention also provides methods for improving the productivity of vitamin K dependent protein expression in a host cell.