Use of iminocyclitols as inhibitors of bacterial adherence to epithelial cells

摘要

It comprises the use of D-fagomine or derivatives thereof in the prevention and/or coadjuvant treatment of bacterial infections, as well as to pharmaceutical, veterinary, or food and feed, pet food compositions containing them.

主权项

1. A method of coadjuvant treating a bacterial infection or microflora imbalance caused by an enteric, oral or respiratory bacteria in a subject by inhibiting the adherence and/or of the agglutination of enteric, oral or respiratory bacteria to epithelial cells, the method comprising administering to the subject a composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are independently selected from the group consisting of H, (C1-C11)-alkyl, and CH2Ph; in such an amount that the compound of formula (I) acts only as a coadjuvant agent; and the bacterial infection is caused by a bacteria selected from the group consisting of Streptococcus mutants, Salmonella tphimurium, Escherichia coli Streptococcus mitis, Streptococcus oralis, Streptococcus gordanii, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium necleatum and Actinomices naeslundii, wherein administering the compound of formula (I) or a pharmaceutically acceptable salt thereof comprises administering the compound of formula (I) or a pharmaceutically acceptable salt thereof at a concentration of from 10 ppm to 40 ppm.