| 发明名称 | Constructs for making induced pluripotent stem cells | ||
| 摘要 | Systems, constructs, and methods for reprogramming cells are provided. In one aspect, for example, a transformation construct for generating iPS cells can include an expression vector having a plurality of reprogramming factors, each reprogramming factor being under control of a separate promoter. | ||
| 申请公布号 | US9228204(B2) | 申请公布日期 | 2016.01.05 |
| 申请号 | US201313975004 | 申请日期 | 2013.08.23 |
| 申请人 | University of Utah Research Foundation | 发明人 | Pulst Stefan M.;Paul Sharan;Dansithong Warunee |
| 分类号 | C12N15/00;C12N15/86;C12N5/074 | 主分类号 | C12N15/00 |
| 代理机构 | Thorpe North & Western LLP | 代理人 | Thorpe North & Western LLP |
| 主权项 | 1. A transformation construct for generating induced pluripotent stem (iPS) cells, comprising: an expression vector including a plurality of reprogramming factors, each reprogramming factor being under control of a separate promoter, wherein the plurality of reprogramming factors includes OCT3/4, SOX2, and at least one member selected from the group consisting of KLF4, c-Myc, NANOG, and LIN28. | ||
| 地址 | Salt Lake City UT US | ||