Anti-tumor bivalent platinum complex and preparation method for complex and ligand of complex

摘要

Platinum complexes containing 3-ketone cyclobutane 1,1-dicarboxylic acid as leaving group for treating cancers and a preparation method of the complexes, one of the platinum complexes is cis-[3-ketone cyclobutane-1,1-dicarboxylic acid radical.diamineplatinum (II)], GSH-5 for short, the chemical structure formula is expressed by formula (1). The other platinum complex is cis-[3-ketone-cyclobutane-1,1-dicarboxylic acid radical.trans-1,2-cyclohexanediamineplatinum (II)], GSH-6 for short, the chemical structure formula is expressed by formula (2). In the formula (2), two chiral carbon atoms marked with * in the trans-1,2-cyclohexanediamine group are both of R forms or S forms.

主权项

1. An antitumor bivalent platinum complex, wherein, 3-ketone cyclobutane-1,1-dicarboxylic acid radical is a leaving group ligand of the platinum complex; the platinum complex may be cis-[3-ketone cyclobutane-1,1-dicarboxylic acid radical.diamineplatinum (II)], abbreviation: GSH-5, and its chemical structure is shown in Formula (1):the platinum complex may also be cis-[3-ketone-1,1-cyclobutane-dicarboxylic acid radical.trans-1,2-cyclohexanediamineplatinum(II)], abbreviation: GSH-6, and its chemical structure is shown in Formula (2):in Formula (2), two chiral carbon atoms marked with * in trans-1,2-cyclohexanediamine group are both R configurations.