Methods for detecting and treating cancer

摘要

The invention generally features compositions and methods for the diagnosis, treatment, and monitoring of neoplasia in a subject, as well as methods of treatment selection.

主权项

1. A method for staging cervical neoplasia in a subject and administering a treatment correlated to a good clinical outcome for the stage of cervical neoplasia, the method comprising:
A) performing an assay to measure the level of a CXCL 12 polypeptide having a molecular weight greater than about 10 kD or 11 kD in the cervical neoplasia; B) comparing the level of the CXCL 12 polypeptide in the cervical neoplasia to a reference level; C) classifying the stage of the cervical neoplasia in the subject as a pre-invasive stage or an invasive stage of cervical neoplasia based on the comparison to the reference level wherein an increase in the level of the CXCL12 polypeptide relative to the reference level indicates an invasive stage and a lack of an increase in the level of the CXCL12 polypeptide relative to the reference level indicates a pre-invasive stage; and D) administering a less aggressive treatment to the subject having a pre-invasive stage of cervical neoplasia, or a more aggressive treatment to the subject having an invasive stage of cervical neoplasiathereby staging cervical neoplasia in the subject and administering a treatment correlated to a good clinical outcome for the stage of cervical neoplasia.