3-phenoxymethylpyrrolidine compounds

摘要

In one aspect, the invention relates to compounds of formula I:;
where R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

主权项

1. A compound of formula I:where:
R1 is isopropyl; R2 through R6 are independently selected from hydrogen, halo, —C1-6alkyl, —CF3, —O —C1-6alkyl, —CN, —C(O)—C1-6alkyl, —S—C1-6alkyl, —C3-8cycloalkyl, and —NO2; or R4 and R5 are taken together to form —CH═CH—CH═CH—; or R5 and R6 are taken together to form —CH═CH—CH═CH—; or a pharmaceutically acceptable salt thereof.