COMPOSITION AND METHOD FOR TREATMENT OF DEPRESSION AND PSYCHOSIS IN HUMANS

摘要

Compositions and methods for the treatment of depression and psychoses in humans are disclosed. More particularly, the invention is directed to formulations containing antipsychotic and/or antidepressant medications and also containing an NMDAR antagonist. The present Invention Is also directed to methods tor the treatment of humans suffering from depression and other psychoses, including, schizophrenia, by administration of the inventive compositions in antidepressant and/or antipsychotic effective amounts.

主权项

1. A method for the treatment of a condition in a human subject selected from the group consisting of depression and suicidality, the method comprising:
administering to the human subject an anti-depression or anti-suicidality effective amount of:
a first compound comprising lurasidone; anda second compound comprising D-cycloserine (DCS) administered at a dose in excess of 500 mg/day, wherein the DCS produces a blood plasma concentration of greater than 25 μg/mL,thereby treating the condition.