| 发明名称 |
NON-COVALENT LOADING OF PLANT PICORNAVIRUS PARTICLES |
| 摘要 |
A method of non-covalently loading a plant picornavirus is described. The method includes contacting a plant picornavirus in solution with a molar excess of a cargo molecule to load the plant picornavirus with the cargo molecule, and then purifying the loaded plant picornavirus. Examples of cargo molecules include imaging agents, antitumor agents, and antiviral agents. Loaded plant picornaviruses prepared in this manner can be used to delivering cargo molecule to cells. |
| 申请公布号 |
US2015376578(A1) |
申请公布日期 |
2015.12.31 |
| 申请号 |
US201414769247 |
申请日期 |
2014.02.18 |
| 申请人 |
CASE WESTERN RESERVE UNIVERSITY |
发明人 |
Steinmetz Nicole;Popkin Daniel |
| 分类号 |
C12N7/00;A61K31/40;A61K31/473;A61K47/46;A61K33/24 |
主分类号 |
C12N7/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of loading a plant picornavirus, comprising contacting a plant picornavirus in solution with a molar excess of at least about 500 fold of a cargo molecule to load the plant picornavirus with the cargo molecule, and
purifying the loaded plant picornavirus. |
| 地址 |
Cleveland, OH US |
