| 发明名称 |
DPP-IV INHIBITOR COMBINED WITH A FURTHER ANTIDIABETIC AGENT, TABLETS COMPRISING SUCH FORMULATIONS, THEIR USE AND PROCESS FOR THEIR PREPARATION |
| 摘要 |
The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and a partner drug, processes for the preparation thereof, and their use to treat certain diseases. |
| 申请公布号 |
US2015366812(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201514836996 |
申请日期 |
2015.08.27 |
| 申请人 |
Boehringer Ingelheim International GmbH |
发明人 |
FRIEDL Thomas;BRAUN Michael;EGUSA Kenji;FUJITA Hikaru;MARUYAMA Megumi;NISHIOKA Takaaki |
| 分类号 |
A61K9/28;A61K31/155;A61K9/20;A61K31/522 |
主分类号 |
A61K9/28 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A pharmaceutical composition comprising or made from:
(a) 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine in a dosage of 2.5 mg or 5 mg, (b) metformin hydrochloride, (c) one or more pharmaceutical excipients, and (d) a basic amino acid having an intramolecular amino group and alkaline characteristics, wherein the pharmaceutical composition is a tablet comprising a film-coat; and wherein the pharmaceutical composition comprises the following amounts (% by weight of total coated tablet mass): 0.1-0.5% of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine, and 47-85% of metformin hydrochloride. |
| 地址 |
Ingelheim am Rhein DE |
