| 发明名称 |
ANTIBODY CONSTRUCTS FOR CDH19 AND CD3 |
| 摘要 |
The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct. |
| 申请公布号 |
US2015368343(A1) |
申请公布日期 |
2015.12.24 |
| 申请号 |
US201414761839 |
申请日期 |
2014.01.27 |
| 申请人 |
AMGEN RESEARCH (MUNICH) GMBH ;AMGEN INC. |
发明人 |
Xiao Shouhua;Pan Zheng;Wickramasinghe Dineli;Jeffries M. Shawn;King Chadwick Terence;Chan Brian Mingtung;Kufer Peter;Lutterbuese Ralf;Raum Tobias;Hoffmann Patrick;Rau Doris;Kischel Roman;Lemon Bryan;Wesche Holger |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated multispecific antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. |
| 地址 |
Munich DE |
