ANTI-TUMOR PHARMACEUTICAL APPLICATION OF PENTACYCLIC TRITERPENE SAPONIN COMPOUNDS OF SZECHUAN MELANDIUM ROOT

摘要

An application of compounds having a structure represented by formula I or a salt thereof and total saponin ingredients containing the compounds in preparing anti-tumor drugs. Researches show that the compounds represented by formula I and the total saponin have strong effects in inhibiting proliferation of human hepatocellular carcinoma cells, human gastric carcinoma cells, human colon cancer cells, human breast cancer cells and a melanoma cell strain, and the compounds represented by formula I, combined with chemotherapeutic drugs, have excellent attenuating and synergistic effects.