Remote assembly of targeted nanoparticles using H-phosphate ENE/-YNE hydrophosphonylation reactions

摘要

The present invention provides phosphonate compounds and methods of preparing the phosphonate compounds so as to allow, for example, increased capability to modify nanoparticles for targeted drug delivery applications.

主权项

1. A compound of the formula: wherein: the bond identified by is a single or double bond; each of L1, L2 and L3 is a bond or a linking group; each of R1 and R2 is an attachment component selected from the group consisting of a C8-C36 alkyl and cholesterol; R3 is a stealth agent wherein the stealth agent is selected from the group consisting of: polyalkylene oxide, polyethylene glycol, a dendrimer, polyvinyl alcohol, polycarboxylate, a polysaccharide, and hydroxyalkyl starch; and R4 is a member selected from the group consisting of H and —P(═O)(OL1-R1)(OL2-R2), wherein when R4 is other than H the bond identified by is a single bond.