| 发明名称 | Replication-defective flavivirus vaccines and vaccine vectors | ||
| 摘要 | This invention provides replication-defective flavivirus vaccines and vaccine vectors, and corresponding compositions and methods. | ||
| 申请公布号 | US9217158(B2) | 申请公布日期 | 2015.12.22 |
| 申请号 | US201213633436 | 申请日期 | 2012.10.02 |
| 申请人 | Sanofi Pasteur Biologics, LLC | 发明人 | Pugachev Konstantin V.;Giel-Moloney Maryann;Kleanthous Harold;Parrington Mark;Zhang Linong |
| 分类号 | A61K39/12;C12N15/86;A61K39/295 | 主分类号 | A61K39/12 |
| 代理机构 | Clark & Elbing LLP | 代理人 | Clark & Elbing LLP ;Michaud Susan M. |
| 主权项 | 1. A replication-deficient pseudoinfectious flavivirus comprising a West Nile virus genome comprising (i) one or more deletions in nucleotide sequences encoding capsid (C) protein, and deletion of the nucleotide sequences encoding pre-membrane (prM) and/or envelope (E) proteins, and (ii) a sequence encoding a heterologous immunogen inserted in place of or in combination with said deletion of the prM and/or E nucleotide sequences, wherein the heterologous immunogen is from a pathogen selected from the group consisting of a rabies virus, influenza virus, respiratory syncytial virus (RSV), and human immunodeficiency virus (HIV). | ||
| 地址 | Cambridge MA US | ||