Protein and lipid biomarkers providing consistent improvement to the prediction of type 2 diabetes

摘要

The invention relates to biomarkers associated with Diabetes, including protein and lipid metabolite biomarkers, methods of using the biomarkers to determine the risk that an individual will develop Diabetes, and methods of screening a population to identify persons at risk for developing Diabetes and other pre-diabetic conditions.

主权项

1. A method of evaluating risk for developing a diabetic condition, the method comprising:
(a) obtaining biomarker measurement data for an individual from at least one biological sample of the individual; wherein the biomarkers comprise: (i) glucose, (ii) protein biomarkers adiponectin, ferritin, and insulin, and (iii) at least one lipid metabolite selected from the lipid metabolites in Table 2; and (b) evaluating the individual's risk for developing a diabetic condition based on an output from a model, wherein the model is executed based on an input of the biomarker measurement data; or wherein the model comprises the measurements of biomarkers by fitting data from a longitudinal study of a population of individuals and the fitted data comprises levels of the biomarkers and conversion to Diabetes in the longitudinal study of the population of individuals.