| 发明名称 |
RECEPTORS OF RSPO2 AND RSPO3 |
| 摘要 |
The present invention relates to the finding that Syndecans (Sdc) are receptors of Rspondin-2 (Rspo2) and Rspondin-3 (Rspo3). Thus, the present invention relates to the identification of Rspo2, Rspo3 and/or Sdc activity modulators by determining if a test compound has the ability to modulate the binding of an Rspo2 and/or Rspo3 polypeptide to an Sdc polypeptide. Further, the invention refers to novel uses for antagonists of Rspo2 and/or Rspo3 in the treatment of Sdc-associated disorders and for Sdc antagonists in the treatment of Rspo2- and/or Rspo3-associated disorders. |
| 申请公布号 |
US2015362489(A1) |
申请公布日期 |
2015.12.17 |
| 申请号 |
US201514593268 |
申请日期 |
2015.01.09 |
| 申请人 |
Deutsches Krebsforschungszentrum |
发明人 |
NIEHRS Christof;GLINKA Andrei;OKAWARA Bisei |
| 分类号 |
G01N33/566;C07K16/18 |
主分类号 |
G01N33/566 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of identifying a modulator of Rspondin-2 (Rspo2), Rspondin-3 (Rspo3) and/or Syndecan (Sdc), i.e. Syndecan-1 (Sdc1), Syndecan-2 (Sdc2), Syndecan-3 (Sdc3) and/or Syndecan-4 (Sdc4) activity, comprising evaluating and/or screening, if a test compound has the ability to modulate binding of an Rspo2 polypeptide or an Rspo3 polypeptide to an Sdc1, Sdc2, Sdc3 and/or Sdc4 polypeptide compared to a control. |
| 地址 |
Heidelberg DE |
