发明名称 |
BIOMARKER FOR PREDICTING RESPONSE OF CLL TO TREATMENT WITH A BTK INHIBITOR |
摘要 |
Disclosed herein are methods for treating an individual diagnosed with a solid tumor or a hematological malignancy, such as chronic lymphocytic leukemia (CLL), for treatment with a Bruton's tyrosine kinase (BTK) inhibitor (e.g., ibrutinib) based on the expression level of miR- 155. Also disclosed herein are methods for assessing whether an individual having a solid tumor or a hematological malignancy such as chronic lymphocytic leukemia (CLL) is responsive or likely to be responsive to therapy with a BTK inhibitor (e.g., ibrutinib). Further disclosed herein are methods of monitoring whether an individual receiving a BTK inhibitor (e.g., ibrutinib) for treatment of a solid tumor or a hematological malignancy such as chronic lymphocytic leukemia (CLL) has relapsed or is likely to have a relapse to therapy. Also disclosed herein are methods of selecting an individual having a solid tumor or a hematological malignancy such as chronic lymphocytic leukemia (CLL) for therapy with a BTK inhibitor (e.g., ibrutinib). |
申请公布号 |
WO2015192081(A1) |
申请公布日期 |
2015.12.17 |
申请号 |
WO2015US35665 |
申请日期 |
2015.06.12 |
申请人 |
BYRD, JOHN C.;GUINN, DAPHNE;JOHNSON, AMY |
发明人 |
GUINN, DAPHNE;JOHNSON, AMY |
分类号 |
C12Q1/68;C12N15/113;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|