DETECTION OF INDIVIDUAL T-CELL REACTION PATTERNS AGAINST TUMOR-ASSOCIATED ANTIGENS (TAA) IN TUMOR PATIENTS AS A BASIS FOR THE INDIVIDUAL THERAPEUTIC VACCINATION OF PATIENTS

摘要

Identifying the preferential target antigens of antitumor T cells comprises isolating T cells from the blood of a tumor patient, transfecting autologous dendritic or B cells with a selection of mRNAs coding for tumor-associated antigens, contacting the T cells with the dendritic or B cells, and identifying the antigens recognized by the T cells. Independent claims are also included for: (1) identifying a tumor in a patient on the basis of an antigen expression pattern determined as above; (2) producing an individualized antitumor vaccine by identifying tumor-associated antigens as above and formulating the antigens as a vaccine; (3) treating a tumor disease on the basis of an antigen expression pattern determined as above. - ACTIVITY : Cytostatic. - MECHANISM OF ACTION : Vaccine.