发明名称 |
Spirocyclic aminoquinolones as GSK-3 inhibitors |
摘要 |
Provided herein are spirocyclic aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK-3 inhibitors mediated diseases. In Formula (I): X1 is O or NR8; A is bond or substituted or unsubstituted C1-C2 alkylene, wherein the substituents when present are selected from one to four Q2 groups; where Q2 is alkyl or haloalkyl; p is 0 or 1; and q is an integer of 0 to 2. |
申请公布号 |
AU2008299862(A1) |
申请公布日期 |
2009.03.19 |
申请号 |
AU20080299862 |
申请日期 |
2008.09.12 |
申请人 |
KYORIN PHARMACEUTICALS CO., LTD;ACTIVX BIOSCIENCES, INC. |
发明人 |
MASAHIRO NOMURA;KATRIN SZARDENINGS;OANA COCIORVA;SHIGEKI SETO;KAZUHIRO YUMOTO;YASUMICHI FUKUDA;YASUSHI KOHNO;AYAKO NAKAMURA;KYOKO OKADA;BEI LI |
分类号 |
C07D498/10;A61K31/4747;A61P25/00;C07D498/20 |
主分类号 |
C07D498/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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