| 摘要 |
The present invention is directed to a chemical compound of the formula
wherein each R1 independently of each other = H, C 1 -C 3 alkyl or a halogen, which is preferably Cl or F; one R2 = R1; the other R2 is - R1, -A - L1 - Phosphoramidite, - A - Ll-Succinyl-solid support, wherein A is selected from a group consisting of - NR5 - CO - , - CO - NR5 -, -NH-CO-NR5-, NH-CS-NR5-, -SO 2 -NR5-, -O-,-CH 2 -; -N(C 1 -C 3 )alkyl -NR5-CO-O- and O-CO-NR5- with R5 = H or C 1 -C 3 -alkyl, further wherein L1 is a nucleosidic or non nucleosidic linker; each R3 independently from each other is - R1 or together with one R4 and one N atom is part of a five or six membered ring; each R4 independently from each other is a base labile protecting group, H, C 1 -C 6 -Alkyl, C 1 -C 6 Sulfo-Alkyl, - L2 - Phosphoramidite, wherein L2 is a nucleosidic or non nucleosidic linker, - L2 - succinyl-solid support, wherein L2 is a nucleosidic or non nucleosidic linker, or together with one R3 and one N atom is part of five or six membered ring; provided that at least one R4 is a base labile protecting group, and there is only one Phosphoramidite moiety or only one linkage ot a solid support. |
