1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them

摘要

1,2,4,5-Tetrahydro-3H-benzazepine compounds (I) and their optical isomers or acid addition salts are new. 1,2,4,5-Tetrahydro-3H-benzazepine compounds of formula (I) and their optical isomers or acid addition salts are new. R 1> : H, 3-7C cycloalkyl, benzyl or alkyl (optionally saturated and substituted by 3-7C cycloalkyl or one or more halo); either R 2>, R 3>, R 4>, R 5> : H, OH, CH 3, -OSO 2R 10>, -OCOR 10>or 1-6C alkoxy (optionally saturated); or R 2>R 3>, R 3>R 4>, R 4>R 5> : -O-(CH 2) q-O-, -O-CH=CH-O- or -O-CH=CH-; either R 6>, R 7>, R 8>, R 9> : H or 1-6C alkoxy (optionally saturated); or R 6>R 7>, R 7>R 8>, R 8>R 9> : -O-(CH 2) q-O-; R 10> : 1-6C alkoxy, NR 11>R11a or 1-6C alkyl (optionally substituted by one or more halo); either R 11>, R11a : H or 1-6C alkyl; or NR 11>R11a : nitrogen containing mono or bicyclic heterocycle ring with 5-8 chains (optionally containing heteroatoms of O or N and substituted by one or more halo); X : O, NH or CH 2; m, p : 0 or 1; and n, q : 1 or 2. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Cardiant; Vasotropic; Antiarrhythmic; Antianginal; Hypotensive; Antidiabetic; Antilipemic. MECHANISM OF ACTION : None given.