NOVEL LIPID-TRIPEPTIDE BASED HYDROGEL-FORMING AGENT AND HYDROGEL

摘要

Disclosed is a hydrogel-forming agent, only a small amount of which enables to form a hydrogel over a wide pH range from acidic to alkaline conditions. Also disclosed is a hydrogel exhibiting high environmental suitability and biocompatibility, while having biodegradability. Specifically disclosed are a hydrogel-forming agent composed of a lipid-peptide represented by the formula (1) below or a salt thereof, and a hydrogel.(1) (In the formula, R1 represents an aliphatic group having 9-21 carbon atoms; R2, R3 and R4 independently represent a hydrogen atom, an alkyl group having 1-4 carbon atoms which may have a branched chain with 1 or 2 carbon atoms, a phenylmethyl group or a -(CH2)n-X group, provided that at least one of R2, R3 and R4 represents a -(CH2)n-X group; n represents a number of 1-4; X represents an amino group, a guanidino group, a -CONH2 group, or a five-membered or six-membered ring which may have 1-3 nitrogen atoms or a fused heterocyclic ring composed of a five-membered and a six-membered ring.)