The present invention describes therapeutic compositions comprising fibroblasts that have been stimulated to increase expression of extracellular matrix components or elastin, or to produce enhanced elastogenesis or the appearance thereof at a site of administration. The therapeutic fibroblast formulations can be prepared using a variety of elastogenic agents, including digests of mammalian elastin, chemically digested plant extracts comprising elastin-like peptides, and synthetic elastogenic peptides. The invention further comprises cosmetic and pharmaceutical treatment methods using the therapeutic fibroblast compositions of the invention.
申请公布号
WO2006125049(A3)
申请公布日期
2008.12.24
申请号
WO2006US19168
申请日期
2006.05.17
申请人
HUMAN MATRIX SCIENCES, LLC;THE HOSPITAL FOR SICK CHILDREN;JIMENEZ, FELIPE;MITTS, THOMAS, F.;HINEK, ALEKSANDER
发明人
JIMENEZ, FELIPE;MITTS, THOMAS, F.;HINEK, ALEKSANDER