SINGLE-STRANDED CYCLIC RNA, AND METHOD FOR PRODUCTION THEREOF

摘要

Disclosed is single-stranded cyclic RNA having a sustained or extended RNA interference activity. The single-stranded cyclic RNA comprises a sense strand sequence, an antisense strand sequence complementary to the sense strand sequence, and two loop sequences which are the same as or different from each other and are located between the sense strand and the antisense strand so as to bind the both strands to each other, wherein the sense strand and the antisense strand are paired to form a stem.