发明名称 Imidazo[1,2-a] pyridine and pyrazo [ 2,3-a] pyridine derivates, method for producing thereof and pharmaceutical composition containing the same
摘要 <p>It is described compound of formula (I) wherein Ring A is imidazol[1,2a]pyrid-3-yl or pyrazolo[2,3a]pyrid-3-yl; R2 is as defined within; m is 0-5; wherein the values of R2 may be the same or different; R1 is as defined within; n is 0 to 2, wherein the values of R1 may be the same or different; Ring B is phenyl or phenyl fused to a C5-7cycloalkyl ring; R3 is as defined within; p is 0-4; wherein the values of R3 may be the same or different; R4 is as defined within; q is 0-2; wherein the values of R4 may be the same or different; and wherein p+q</=5; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the inhibition of cell cycle kinases CDK2, CDK4, and CDK6 are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.</p>
申请公布号 SK287033(B6) 申请公布日期 2009.10.07
申请号 SK20020000240 申请日期 2000.08.15
申请人 ASTRAZENECA AB 发明人 THOMAS ANDREW PETER;BREAULT GLORIA ANNE;BEATTIE JOHN FRANKLIN;JEWSBURY PHILLIP JOHN
分类号 A61K31/437;A61K31/506;A61K31/5377;A61K31/63;A61P9/00;A61P9/10;A61P11/00;A61P13/12;A61P17/06;A61P19/08;A61P21/00;A61P27/02;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P43/00;C07D221/00;C07D231/00;C07D235/00;C07D471/04 主分类号 A61K31/437
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