METABOLITES AND DERIVATIVES OF AMBRISENTAN

摘要

The invention relates to derivatives and metabolites of ambrisentan, including compounds of general Formula (I) or salts, hydrates, solvates, racemates, or optical isomers thereof, wherein R1 is—OH or—OCH3; R2 is—H, lower alkyl (e.g. C1-C4 alkyl) or glycosidyl; and R3 and R4 are independently—CH3,—C(O)H or—CH2OR6, wherein R6 is—H or a hydrocarbyl group having 1 to 20 carbon atoms.