ASYMMETRIC CARBON-CARBON BOND-FORMING REACTION TO WHICH CATALYTIC FUNCTION IS IMPOSED BY BIFUNCTIONAL CINCHONA-ALKALOID

摘要

PROBLEM TO BE SOLVED: To provide a catalytic asymmetric synthetic method for chiral compounds from prochiral substrates such as a nitroalkene, alkenyl sulfone, alkenyl ketone, etc., and a catalyst therefore for producing enantiomerically pure compound in order to ensure large effectiveness and reduction in the side-effects in the pharmaceutical industry.

SOLUTION: Disclosed are a compound which is a quinine-based catalyst and a quinidine-based catalyst and represented by formula III, and a step of reacting prochiral β-cyanoketones, prochiral β-ketoesters, etc., with an electron deficient alkene in the presence of the catalyst, thereby producing chiral non-racemic β-cyanoketones, chiral non-racemic β-ketoesters, etc.

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