| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a vaccine capable of inducing a strong and continuous T-cell response, which is useful for treating tumors and chronic viral diseases, allergies and other chronic diseases, in particular. <P>SOLUTION: Virus-like particles (VLPs) are loaded with immunostimulatory substances, wherein CpG-VLPs loaded with DNA oligonucleotides containing non-methylated C and G (CpG) exhibit remarkably higher immunogenicity than that of their CpG-free counterparts and induce enhanced B- and T-cell responses, in particular. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T-cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to the CpG-loaded VLPs may therefore be suitable vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases. <P>COPYRIGHT: (C)2009,JPO&INPIT</p> |
