NOVEL C-21-KETO LUPANE DERIVATIVES PREPARATION AND USE THEREOF
摘要
The invention relates to 21 -keto triterpene compounds of formula (I): wherein R1, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
申请公布号
WO2009082818(A8)
申请公布日期
2009.09.03
申请号
WO2008CA02290
申请日期
2008.12.23
申请人
VIROCHEM PHARMA INC.;MOINET, CHRISTOPHE;COURCHESNE, MARC;HALAB, LILIANE;CHAURET, NATHALIE;CHAN CHUN KONG, LAVAL
发明人
MOINET, CHRISTOPHE;COURCHESNE, MARC;HALAB, LILIANE;CHAURET, NATHALIE;CHAN CHUN KONG, LAVAL