发明名称 |
LISTERIA-BASED AND LLO-BASED VACCINES |
摘要 |
<p>This invention provides methods of treating and vaccinating against an antigen-expressing tumor and inducing an immune response against a sub-dominant epitope of antigen, comprising a fusion of an LLO fragment to the antigen or a recombinant Listeria strain expressing the antigen. The present invention also provides recombinant peptides comprising a listeriolysin (LLO) protein fragment fused to a Her-2 protein or fragment thereof, recombinant Listeria strains expressing a Her-2 protein, vaccines and immunogenic compositions comprising same, and methods of inducing an anti-Her-2 immune response and treating and vaccinating against a Her-2-expressing tumor, comprising same.</p> |
申请公布号 |
EP1804831(A4) |
申请公布日期 |
2009.09.02 |
申请号 |
EP20050811815 |
申请日期 |
2005.09.14 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
PATERSON, YVONNE;SINGH, RESHMA |
分类号 |
C07K19/00;A01N63/00;A61K39/00;A61K39/02;A61K39/09;A61K39/39;C12N15/62 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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