NEUROTROPHIC FACTOR MANF AND USES THEREOF

摘要

The present invention generally relates to the field of treatment of neuronal disorders and more particularly to neurotrophic factor MANF and uses thereof. The present invention provides a pharmaceutical compound comprising MANF nucleic acid molecule, MANF protein or a functional fragment thereof for the treatment of a peripherial neuropathy including Alzheimer's disease, Parkinson's disease, epilepsy, drug addiction and ischemic brain injury.

主权项

1. A method of treatment of an individual having Alzheimer's disease, Parkinson's disease, epilepsy, drug addiction or ischemic brain injury, said method comprising:
administering to the individual a therapeutically effective amount of MANF polypeptide comprising the amino acid sequence of SEQ ID NO:2 or a functional fragment thereof, wherein said polypeptide is a mesencephalic astrocyte-derived neurotrophic factor (MANF) polypeptide, and wherein said functional fragment is a MANF polypeptide having SEQ ID NO:4 and is capable of preventing the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons.