主权项 |
1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from CH3, CH2D, CHD2, and CD3; R2 is CH3 or CD3; R3 is selected from CH3, CH2D, CHD2, CD3, CF3, CHF2, CH2F, CDF2, and CD2F; R4 is an ethyl group substituted with zero to five deuterium, or is a cyclopentyl group substituted with zero to nine deuterium; X is C═O; each of Y1a, Y1b, Y2, Y3, Y4, Y5, Y7 and Y8 is; and Y6 is selected from Cl, H, and D; provided that if R1 is CH3; R2 is not substituted with deuterium; R3 is CH3, CF3, CHF2, or CH2F; and Y6 is Cl or H; then R4 is an ethyl group substituted with one to five deuterium or a cyclopentyl group substituted with one to nine deuterium. |