Treatment and prevention of dental pathology in humans and non-human animals

摘要

The present invention relates to methods and compositions for inhibiting, treating, and preventing dental diseases in human and non-human animals, particularly domesticated companion animals. More particularly, the present invention relates to the unexpected discovery that the combination of micron-sized particulate bioactive glass and a topical bisphosphonate yields a composition that is capable of treating and/or preventing dental problems such as periodontal disease, tooth decay and tooth resorption in animals, particularly small mammals such as cats.

主权项

1. A composition for the treatment of dental pathology in a mammal, said composition comprising a therapeutically effective amount of micron-sized dentinal tubule-occluding particulates of a sol-gel derived or melt-derived bioactive glass having an average particle size of less than 10 microns, wherein said bioactive glass consists of:
a. 40 to 60 wt % SiO2 if melt-derived or at least 65 wt % SiO2 if sol-gel derived; b. 10 to 30 wt % CaO, 0 to 5 wt % MgO, and/or 0 to 25 wt % CaF2; c. 10 to 35 wt % Na2O and/or 0 to 8 wt % K2O; d. 2 to 8 wt % P2O5; e. 0 to 10 wt % B2O3 f. 0 to 1.5 wt % Al2O3 g. 0 to 15 wt % silver oxide; and h. at least one bisphosphonate.