Monoclonal antibodies and method of immunological analysis of D-dimer

摘要

Provided are an antibody capable of specifically and accurately measuring digested products of stabilized fibrin (D-dimer), and a method and a reagent for measuring D-dimer using the antibody. The antibody specifically reacts with D-dimer, which is plasmin-digested products of stabilized fibrin, but does not react with fibrinogen or plasmin-digested products of fibrinogen, which include fragment X, fragment Y, fragment D1, and fragment E3, and does not react with dissociation products of DD/E monomer, which include fragment DD, fragment E1, and fragment E2.

主权项

1. An anti-D-dimer antibody, which specifically reacts with a D-dimer, wherein the D-Dimer is a plasmin digested product of stabilized fibrin, but does not react with (1), (2) and (3) as follows:
(1) Fibrinogen, (2) fragment X, fragment Y, fragment D1 and fragment E3, which are plasmin-digested products of fibrinogen; and (3) fragment DD, fragment E1 and fragment E2, which are dissociation products of a DD/E monomer, wherein said DD/E monomer is a basic unit of plasmin-digested products of stabilized fibrin.