Collection system for purification flowstreams

摘要

A collection system for collecting samples from a flowstream (5) exiting a supercritical fluid chromatography system is provided. The collection system comprises: (i) a first back pressure regulator (10) on the flowstream as it exits the chromatography system, (ii) a gas-liquid separator (30) having a tapered and angled dripper (65), which introduces the flow into the separator at an angle tangential to the separator wall; and (iii) one or more fraction collectors (15), wherein the fraction collector is at a reduced pressure collection point, between 100 bar and atmospheric pressure. A collection system for HPLC is also provided, as well as a process for collection of samples from a flowstream.

主权项

1. A process for collecting samples in a flow stream from a supercritical fluid chromatography system, the flowstream having gas and liquid components, the process comprising the steps of:
i) reducing the pressure of the flow stream to a pressure between system pressure and atmospheric pressure; ii) optionally, heating the flow stream; iii) separating the gas and liquid components in a separator having a tapered and angled dripper which introduces the flow to the separator at an angle tangential to the separator wall; and iv) collecting the samples in collection vessels which are at a pressure between atmospheric pressure up to a pressure below system pressure.