摘要 |
The present invention provides an Ras activity inhibitor which is safe and effective for therapy for cancer, RAS/MAPK syndrome and the like. Specifically provided is an Ras activity inhibitor which contains a compound represented by formula (I), or a pharmaceutically acceptable salt, hydrate, solvate or prodrug of the compound. (In the formula, -X- represents a group represented by formula (AA) or a single bond; n represents 0, 1 or 2; R1 represents a halogen atom, an optionally substituted alkyl group or an optionally substituted alkoxy group, and in cases where a plurality of R1 moieties are present, the R1 moieties are the same as or different from each other; -Y represents a group represented by formula (BB) or a group represented by -NH-R2; and R2 represents an optionally substituted alkyl group, an optionally substituted aryl group, an optionally substituted arylcarbonyl group, an optionally substituted alkoxycarbonyl group, an optionally substituted alkylcarbonyl group, an optionally substituted heterocyclic group, an optionally substituted heterocyclic carbonyl group or an optionally substituted thiocarbonyl group.) |