SYSTEMS AND METHODS FOR COMPREHENSIVE ANALYSIS OF MOLECULAR PROFILES ACROSS MULTIPLE TUMOR AND GERMLINE EXOMES
摘要
Omics patient data are analyzed using sequences or diff objects of tumor and matched normal tissue to identify patient and disease specific mutations, using transcriptomic data to identify expression levels of the mutated genes, and pathway analysis based on the so obtained omic data to identify specific pathway characteristics for the diseased tissue. Most notably, many different tumors have shared pathway characteristics, and identification of a pathway characteristic of a tumor may thus indicate effective treatment options ordinarily not considered when tumor analysis is based on anatomical tumor type only.
申请公布号
WO2015184439(A1)
申请公布日期
2015.12.03
申请号
WO2015US33497
申请日期
2015.06.01
申请人
FIVE3 GENOMICS, LLC;RABIZADEH, SHAHROOZ;SOON-SHIONG, PATRICK
发明人
RABIZADEH, SHAHROOZ;SOON-SHIONG, PATRICK;SANBORN, JOHN ZACHARY;VASKE, CHARLES JOSEPH;BENZ, STEPHEN CHARLES